Product Description
STAT6 (signal transducer and activator of transcription 6) is a member of the STAT family of cytoplasmic transcription factors, which regulate gene expression by transmitting signals to the nucleus and binding to specific DNA promoter sequences. STAT6 is composed of a DNA-binding domain, a C-terminal transcriptional activation domain, and a SH2 domain. STAT signaling is critical for cellular processes such as embryonic development, immune tolerance and tumor surveillance, and regulation of cell differentiation, growth, and apoptosis. (1,2) Nuclear expression of STAT6 is found in nearly all cases of solitary fibrous tumor (SFT) and is very limited in other soft tissue neoplasms making it a highly sensitive and specific immunohistochemical marker for SFT and may help to distinguish this tumor type from histologic mimics. Recently, STAT6 has received considerable attention in the area of tumor growth and metastasis. Significantly higher STAT6 immunoexpression level was observed in non-small-cell lung cancer (NSCLC); specifically, higher expression was found in squamous cell carcinoma than in large-cell carcinoma. (2,3)